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Bay 41-4109

CAS No. 298708-81-3

Bay 41-4109( Bay-414109 )

Catalog No. M13917 CAS No. 298708-81-3

A potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    Bay 41-4109
  • Note
    Research use only, not for human use.
  • Brief Description
    A potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM.
  • Description
    A potent, non-nucleosidic inhibitor of HBV nucleocapsid maturation with IC50 of 0.05 uM; reduces HBV core protein levels in cell culture, possess in vitro and in vivo antiviral activity. HBV infection Discontinued.
  • In Vitro
    BAY 41-4109 is able to both accelerate and misdirect capsid assembly in vitro. Preformed capsids are stabilized by BAY 41-4109, up to a ratio of one inhibitor molecule per two dimers. BAY 41-4109 is equally effective at inhibiting HBV DNA release and the cytoplasmic HBcAg level, with IC50s of 32.6 and 132 nM in HepG2.2.15 cells, respectively. HBV DNA and HBcAg are inhibited in a dose-dependent manner, indicating that the anti-HBV mechanisms are associated with and dependent on the rate of HBcAg inhibition.
  • In Vivo
    BAY 41-4109 reduces viral DNA in the liver and in the plasma dose-dependently with efficacy comparable to 3TC. BAY 41 -4109 reduces hepatitis B virus core antigen (HBcAg) in livers of HBV-transgenic mice. Pharmacokinetic studies in mice have shown rapid absorption, a bioavailability of 30% and dose-proportional plasma concentrations, about 60% in rats and dogs.BAY41-4109 inhibits virus production in vivo by a mechanism that targets the viral capsid.
  • Synonyms
    Bay-414109
  • Pathway
    Microbiology/Virology
  • Target
    HBV
  • Recptor
    HBV
  • Research Area
    Infection
  • Indication
    HBV Infection

Chemical Information

  • CAS Number
    298708-81-3
  • Formula Weight
    395.7629
  • Molecular Formula
    C18H13ClF3N3O2
  • Purity
    >98% (HPLC)
  • Solubility
    DMSO: ≥ 44 mg/mL
  • SMILES
    O=C(C1=C(C)NC(C2=NC=C(F)C=C2F)=N[C@H]1C3=CC=C(F)C=C3Cl)OC
  • Chemical Name
    5-Pyrimidinecarboxylic acid, 4-(2-chloro-4-fluorophenyl)-2-(3,5-difluoro-2-pyridinyl)-1,4-dihydro-6-methyl-, methyl ester, (4R)-

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Deres K, et al. Science. 2003 Feb 7;299(5608):893-6. 2. Weber O, et al. Antiviral Res. 2002 May;54(2):69-78. 3. Brezillon N, et al. PLoS One. 2011;6(12):e25096.
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